1. Same Value, Two Byte Orders
A 32-bit integer is conceptually one number, but in RAM it lives across four byte-sized addresses. Little-endian stores the least-significant byte first; big-endian stores the most-significant byte first. Modern x86, x86_64, and ARM (in its usual mode) are all little-endian.
2. The Same Bytes, Four Valid Readings
You've opened a chunk of memory in your debugger. The same 8 bytes can be interpreted as a string, as a string of small integers, or as larger integers, and the "larger integer" interpretation flips depending on the machine's endianness. This is the #1 source of "why does my disassembler show a different value than my hex dump" confusion.
3. The Return-Address Trick (Exploit Payloads)
If you've read the buffer overflow walk-through (or written your first exploit), this is the mistake that catches everyone: when you overwrite a return address, you write the bytes backwards, because that's what the CPU will read back. This section connects "little-endian" to "why does my Python payload look reversed".
4. File Format Magic Numbers
Almost every binary file format starts with a short fixed byte sequence called a "magic number" that identifies it. They're usually picked so the bytes look like recognizable ASCII (so you can spot them in a hex dump), but if you ever see them quoted as integers (in source code, in docs), endianness flips the value.
5. Why x86 Chose Little-Endian (the Useful "Why")
The "which way is more natural" debate is usually settled with "big-endian matches how humans write numbers, so it's more natural". That's not wrong, but there's a real engineering reason little-endian won on consumer CPUs: it makes type widening free.